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The independent and interactive associations of physical activity intensity and vitamin D status with bone mineral density in prepubertal children: the PANIC Study.
Plain-language guide to PMID 33547487 (2021): controlled clinical trial of Vitamin D, K2, Magnesium and Zinc in 366 children.
Key Facts
- PMID
- 33547487
- Journal
- Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
- Year
- 2021
- Study type
- Controlled Clinical Trial
- Authors
- Constable AM et al. (11 authors)
- DOI
- 10.1007/s00198-021-05872-z
- Registered trial
- NCT01803776
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a controlled clinical trial.
It is unclear how physical activity intensity and vitamin D status are related to bone health in prepubertal children.
The researchers found positive associations between vitamin D status and moderate-to-vigorous physical activity with bone in boys and girls.
Who Took Part
The study group was 366 children.
The age groups tagged for this paper are children, both men and women.
The participants were 366 prepubertal Finnish children (190 boys, 176 girls) aged 6-8 years.
How the Study Was Run
Linear regression analysed the associations of sedentary time (ST), light PA (LPA), moderate PA (MPA), moderate-to-vigorous PA (MVPA) and vigorous PA (VPA) measured by accelerometery, and serum 25(OH)D with total body less head (TBLH) and lower-limb aBMD, measured by dual-energy X-ray absorptiometry.
What Was Measured
The sex-specific independent and interactive associations of physical activity (PA) intensity and serum 25-hydroxyvitamin D (25(OH)D) levels with areal bone mineral density (aBMD) were investigated in prepubertal children.
PubMed files the paper under topics including Absorptiometry, Photon, Bone Density, Exercise, Sedentary Behavior and Vitamin D.
The authors tagged it with the keywords Accelerometery, Bone mass, Childhood, DXA and Growth.
What This Means in Plain Language
This is a controlled clinical trial of Vitamin D, K2, Magnesium and Zinc in 366 children.
With several hundred people or more, it is a fairly large study for this kind of research.
Results are reported in around 7 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 2021 (Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA), a journal based in England.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.