Vitamin D supplementation among Bangladeshi children under-five years of age hospitalised for severe pneumonia: A randomised placebo controlled trial.

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

Vitamin D is important for its immunomodulatory role and there is an independent association between vitamin D deficiency and pneumonia.

The researchers assessed the effect of vitamin D supplementation on the outcome in children hospitalized for severe pneumonia.

Who Took Part

PubMed indexes the participants as infants and young children, both men and women.

This was a randomised, double blinded, placebo-controlled clinical trial in children aged >2-59 months with severe pneumonia attending Dhaka Hospital, icddr,b.

How the Study Was Run

The design is described as randomized, double-blind and placebo-controlled.

The participants were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

Blinding on both sides kept the participants and researchers unaware of who received Vitamin D, K2, Magnesium and Zinc.

The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.

This trial is registered at ClinicalTrials.gov, number NCT02185196.

What Was Measured

The researchers assessed the effect of vitamin D supplementation on the outcome in children hospitalized for severe pneumonia.

Topics PubMed links to this paper include Bangladesh, Hospitalization, Nutrition Therapy, Pneumonia and Vitamin D.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.

Its findings take up roughly 5 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2021 (PloS one), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.