Prevalence of brain MRI findings in children with nonacquired growth hormone deficiency: a systematic review and meta-analysis.

What It Covers

Researchers studied Exogenous HGH, sermorelin & older GHRPs (why they're passed over) in this meta-analysis publication.

To verify and integrate the prevalence and phenotype of abnormalities in the sellar region in patients with growth hormone deficiency (GHD) using MRI data.

The inclusion criteria were as follows: (1) pediatric patients diagnosed with nonacquired GHD and (2) detailed data sufficient to assess the proportion of sellar and parasellar abnormalities on brain MRI scans.

Who the Included Studies Covered

PubMed indexes the participants as young children, children and teenagers.

Finally, thirty-two studies with 39,060 children (mean or median age, 3.4-14.1 years) were included.

How the Review Was Done

The researchers searched PubMed and EMBASE up to December 14, 2020.

The number and type of MRI findings from all included studies were pooled by two authors.

The heterogeneity across studies was evaluated with the Q test or the inconsistency index (I2) statistic.

Subgroup analyses were performed according to the type of GHD (isolated GHD [IGHD] vs. multiple pituitary hormone deficiency [MPHD]), MRI magnet, geographical region, and cutoff serum growth hormone (GH) level.

What Was Measured

The subject headings attached to it are Human Growth Hormone, Magnetic Resonance Imaging, Neuroimaging, Pituitary Gland and Prevalence.

Author keywords: Brain, Growth hormone deficiency, MRI, Meta-analysis and Pediatric.

What This Means in Plain Language

This is a meta-analysis of Exogenous HGH, sermorelin & older GHRPs (why they're passed over).

Results are reported in around 4 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2021 (Neuroradiology), a journal based in Germany.

More context: the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) compound page, all human trials.