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Beneficial Effects of Intravenous Magnesium Administration During Robotic Radical Prostatectomy: A Randomized Controlled Trial.
Plain-language guide to PMID 33611742 (2021): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 52 patients.
Key Facts
- PMID
- 33611742
- Journal
- Advances in therapy
- Year
- 2021
- Study type
- Randomized Controlled Trial
- Authors
- Kim HY et al. (6 authors)
- DOI
- 10.1007/s12325-021-01643-8
- Registered trial
- NCT02833038
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.
This study aimed to evaluate the effects of intravenous magnesium administration on hemodynamics and the stress response in patients undergoing robotic radical prostatectomy.
Why It Was Studied
Robotic radical prostatectomy requires prolonged pneumoperitoneum and a steep Trendelenburg position.
Magnesium can attenuate the stress response and hemodynamic perturbations.
Who Took Part
The study group was 52 patients.
PubMed tags the participants as men only.
In this prospective, double-blind, randomized controlled study, 52 patients undergoing robotic radical prostatectomy were randomized into two groups: 26 in the magnesium group and 26 in the control group.
How the Study Was Run
The researchers set it up as a randomized and double-blind study.
The patients were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.
Neither the patients nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.
The primary outcomes were the changes in heart rate and mean arterial pressure (MAP) during surgery.
The serum stress hormones (adrenocorticotropic hormone, cortisol, epinephrine, and norepinephrine) were also measured.
What Was Measured
The subject headings attached to it are Laparoscopy, Magnesium, Prostatectomy and Robotic Surgical Procedures.
Author keywords: Hemodynamic, Pain, Robotic prostatectomy and Stress hormone.
What This Means in Plain Language
The paper is a randomized and double-blind study of Vitamin D, K2, Magnesium and Zinc in 52 patients.
Its findings take up roughly 5 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.
The publication is from 2021 (Advances in therapy), a journal based in United States.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.