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Efficacy and safety of a supplement combination on hand pain among people with symptomatic hand osteoarthritis an internet-based, randomised clinical trial the RADIANT study
Plain-language guide to PMID 33617972 (2021): double-blind randomized controlled trial of DMSO (dimethyl sulfoxide, non-peptide solvent).
Key Facts
- PMID
- 33617972
- Journal
- Osteoarthritis and cartilage
- Year
- 2021
- Study type
- Randomized Controlled Trial
- Authors
- Liu X et al. (8 authors)
- DOI
- 10.1016/j.joca.2021.01.011
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of DMSO (dimethyl sulfoxide, non-peptide solvent), published as a randomized controlled trial.
Who Took Part
The age groups tagged for this paper are older adults, both men and women.
How the Study Was Run
In design terms this was a randomized, double-blind and placebo-controlled study.
Because people in this DMSO (dimethyl sulfoxide, non-peptide solvent) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
As a double-blind DMSO (dimethyl sulfoxide, non-peptide solvent) study, the assignments were hidden from both participants and investigators until the end.
A placebo (an inactive look-alike) gave the DMSO (dimethyl sulfoxide, non-peptide solvent) group a baseline to be compared against.
This was an internet-based, double-blind, randomised, placebo-controlled trial.
The primary outcome was change in hand pain assessed using a visual analogue scale (VAS 0-100) from baseline to week 12.
A range of secondary outcomes and additional measures were recorded.
What Was Measured
The subject headings attached to it are Anti-Inflammatory Agents, Boswellia, Curcumin, Dimethyl Sulfoxide, Hand, Osteoarthritis and Pinus.
The authors tagged it with the keywords And curcumin, Boswellia serrata extract, MSM, Pine bark extract and Supplement combination.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of DMSO (dimethyl sulfoxide, non-peptide solvent).
The abstract goes on to report its results in about 6 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2021 (Osteoarthritis and cartilage), a journal based in England.
More context: the DMSO (dimethyl sulfoxide, non-peptide solvent) compound page, all human trials.
Our Notes on the Compound
DMSO (dimethyl sulfoxide, non-peptide solvent): A solvent that carries substances through skin and into the blood, described as a free-radical scavenger; not a peptide.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.