Vitamin D Supplementation for Prevention of Cancer: The D2d Cancer Outcomes (D2dCA) Ancillary Study.

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.

In a population with prediabetes and overweight/obesity that is at higher risk of cancer than the general population, the researchers sought to determine if vitamin D supplementation lowers the risk of cancer and precancers.

Who Took Part

PubMed indexes the participants as middle-aged adults and older adults, both men and women.

Participants had prediabetes and overweight/obesity and were free of cancer for the previous 5 years.

How the Study Was Run

The design is described as randomized and placebo-controlled.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

A placebo (an inactive look-alike) gave the Vitamin D, K2, Magnesium and Zinc group a baseline to be compared against.

The Vitamin D and type 2 diabetes (D2d) cancer outcomes study (D2dCA) is an ancillary study to the D2d study, which was conducted at 22 academic medical centers in the United States.

At scheduled study visits (4 times/year), cancer and precancer events were identified by questionnaires.

Clinical data were collected and adjudicated for all reported events.

What Was Measured

PubMed files the paper under topics including Dietary Supplements, Neoplasms, Obesity, Overweight, Precancerous Conditions, Prediabetic State and Proportional Hazards Models.

The authors tagged it with the keywords clinical trial, colorectal polyps, prediabetes and vitamin D.

What This Means in Plain Language

The paper is a randomized and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.

The abstract goes on to report its results in about 5 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2021 (The Journal of clinical endocrinology and metabolism), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.