Association of genetic polymorphisms in vitamin D receptor (ApaI, TaqI and FokI) with vitamin D and glycemic status in type 2 diabetes patients from Southern India.

What Was Tested

This observational study looks at Vitamin D, K2, Magnesium and Zinc.

To evaluate the association of VDR polymorphisms (FokI, TaqI and ApaI) with vitamin D levels and glycemic status in type 2 diabetes patients from Southern India.

Who Took Part

The study group was 2 patients.

In this observational study, genotype frequencies and vitamin D levels of 200 cases (type 2 diabetes patients) were compared with 300 controls (unrelated anonymised stored samples of healthy volunteers) from south India.

How the Study Was Run

Serum 25 (OH) D levels were measured by immunoassay technique, glycated hemoglobin (HbA1c) was measured using HPLC and genotyping of VDR polymorphisms were carried out using Real time Polymerase Chain Reaction (RT PCR).

What Was Measured

Topics PubMed links to this paper include Blood Glucose, Case-Control Studies, Diabetes Mellitus, Type 2, Genetic Predisposition to Disease, India, Polymorphism, Genetic and Receptors, Calcitriol.

Author keywords: VDR polymorphisms, glycemic status, type 2 diabetic mellitus, vitamin D deficiency and vitamin D receptor (VDR).

What This Means in Plain Language

This is an observational study of Vitamin D, K2, Magnesium and Zinc in 2 patients.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

Results are reported in around 5 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2021 (Drug metabolism and personalized therapy), a journal based in Germany.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.