The effects of magnesium supplementation on serum level of brain derived neurotrophic factor (BDNF) and depression status in patients with depression.

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.

Therefore, the purpose of this clinical trial was to determine effect of magnesium supplementation on serum Level of BDNF, magnesium and depression status in patients with depression.

Who Took Part

The study group was 46 subjects.

A double blind randomized clinical trial was conducted on 46 depressed subjects.

How the Study Was Run

The design is described as randomized, double-blind and placebo-controlled.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Blinding on both sides kept the subjects and researchers unaware of who received Vitamin D, K2, Magnesium and Zinc.

A placebo (an inactive look-alike) gave the Vitamin D, K2, Magnesium and Zinc group a baseline to be compared against.

Beck's test was conducted and blood samples were taken at baseline and after the intervention period for analysis of serum magnesium and BDNF.

What Was Measured

Topics PubMed links to this paper include Brain-Derived Neurotrophic Factor, Depression, Dietary Supplements and Magnesium.

The authors tagged it with the keywords BDNF, Beck's test, Brain derived neurotrophic factor and Randomized clinical trial.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 46 subjects.

Its findings take up roughly 3 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2021 (Clinical nutrition ESPEN), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.