Causal effects of dietary calcium, zinc and iron intakes on coronary artery disease in men: G-estimation and inverse probability of treatment weighting (IPTW) analyses.

Plain-language guide to PMID 33745624 (2021): randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 466 participants.

Key Facts

PMID: 33745624
Journal: Clinical nutrition ESPEN
Year: 2021
Study type: Randomized Controlled Trial
Authors: Basnet TB et al. (5 authors)
DOI: 10.1016/j.clnesp.2020.12.030
Registered trial: NCT00123456

What This Study Did, in Plain Language

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

However, the results of previous studies were not uniform across different countries.

The current study aims to determine the causal effects of dietary calcium, zinc, and iron intakes on coronary artery disease (CAD) among Nepalese men.

G-estimation and inverse probability treatment weighting (IPTW) analyses were performed to determine the causal odds of CAD due to dietary calcium, zinc, and iron intakes.

Who Took Part

According to the abstract, 466 participants were involved.

PubMed tags the participants as men only.

Dietary intakes of 466 male participants over the past 12 months were evaluated using a semi-quantitative customized food frequency questionnaire.

How the Study Was Run

The design is described as randomized.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

A matched case-control study was carried out at Shahid Gangalal National Heart Center.

What Was Measured

PubMed files the paper under topics including Calcium, Dietary, Case-Control Studies, Coronary Artery Disease, Iron, Probability and Zinc.

Author keywords: Case-control study, Coronary heart disease, Dietary minerals, Nepal and Nutrients.

What This Means in Plain Language

The paper is a randomized study of Vitamin D, K2, Magnesium and Zinc in 466 participants.

With several hundred people or more, it is a fairly large study for this kind of research.

Its findings take up roughly 9 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2021 (Clinical nutrition ESPEN), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.

Our Notes on the Compound

Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.

Vitamin D, K2, Magnesium and Zinc in the library

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.