Evaluation of macular, retinal nerve fiber layer and choroidal thickness by optical coherence tomography in children and adolescents with vitamin B12 deficiency.

What Was Tested

This observational study looks at Cyanocobalamin (Vitamin B12).

To investigate macular, Retinal Nerve Fiber Layer (RNFL) and choroidal thickness in children and adolescents with vitamin B12 deficiency and no neurological examination finding.

Why It Was Studied

This study is an observational study.

Who Took Part

The study group was 30 children.

By PubMed's age tags, the people studied were children and teenagers.

The study group includes of thirty-three children aged 8-17 years who were brought to the Pediatric outpatient clinic with the symptoms of fatigue and forgetfulness and whose Vitamin B12 levels were detected < 200 pg/ml.

The control group was the 30 children and adolescents applied to the same policlinic with various symptoms and whose Vitamin B12 levels were found normal.

How the Study Was Run

Children and adolescents with chronic systemic/ocular disease history and myopia or hyperopia more than 4 diopters were not included in both groups.

Spectral Domain-Optical Coherence Tomography (SD-OCT) was used for measurements.

What Was Measured

The subject headings attached to it are Choroid, Nerve Fibers, Tomography, Optical Coherence, Vitamin B 12 and Vitamins.

Author keywords: Adolescent, Children, Choroid thickness, Macula, RNFL and Vitamin B12 deficiency.

What This Means in Plain Language

This is an observational study of Cyanocobalamin (Vitamin B12) in 30 children.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

Results are reported in around 5 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2021 (International ophthalmology), a journal based in Netherlands.

More context: the Cyanocobalamin (Vitamin B12) compound page, all human trials.