Lidocaine combined with magnesium sulfate preserved hemodynamic stability during general anesthesia without prolonging neuromuscular blockade: a randomized, double-blind, controlled trial.

Plain-language guide to PMID 33773580 (2021): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 64 patients.

Key Facts

PMID: 33773580
Journal: BMC anesthesiology
Year: 2021
Study type: Randomized Controlled Trial
Authors: Paula-Garcia WN et al. (4 authors)
DOI: 10.1186/s12871-021-01311-y
Registered trial: NCT02483611

What This Study Did, in Plain Language

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.

The present study evaluated the effects of these drugs, isolated or combined, on hemodynamic parameters as well as on the cisatracurium-induced neuromuscular blockade (NMB).

Who Took Part

According to the abstract, 64 patients were involved.

By PubMed's age tags, the people studied were adults, both men and women.

At a university hospital, 64 patients, ASA physical status I and II, undergoing elective surgery with similar pain stimuli were randomly assigned to four groups.

How the Study Was Run

The researchers set it up as a randomized and double-blind study.

The patients were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.

Hemodynamic parameters and neuromuscular blockade features were continuously monitored until spontaneous recovery of the train of four (TOF) ratio (TOFR > 0.9).

What Was Measured

The present study evaluated the effects of these drugs, isolated or combined, on hemodynamic parameters as well as on the cisatracurium-induced neuromuscular blockade (NMB).

PubMed files the paper under topics including Analgesics, Anesthesia, General, Anesthetics, Local, Arterial Pressure, Atracurium, Drug Combinations and Heart Rate.

Author keywords: General anesthesia, Hemodynamic parameters, Lidocaine, Magnesium sulfate and Neuromuscular blockade.

What This Means in Plain Language

The paper is a randomized and double-blind study of Vitamin D, K2, Magnesium and Zinc in 64 patients.

Results are reported in around 9 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2021 (BMC anesthesiology), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.

Our Notes on the Compound

Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.

Vitamin D, K2, Magnesium and Zinc in the library

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.