Growth hormone deficiency and the transition from pediatric to adult care.

What It Covers

Researchers studied Exogenous HGH, sermorelin & older GHRPs (why they're passed over) in this review publication.

To discuss the approach to patients diagnosed with growth hormone deficiency (GHD) in childhood during the transition period from puberty to adulthood, focusing on the following: (1) physiology; (2) effects of recombinant human GH (rhGH) interruption/reinstitution after adult height achievement; (3) re-evaluation of somatrotropic axis; (4) management of rhGH reinstitution, when necessary.

Why It Was Studied

Narrative review of the literature published at PubMed/MEDLINE until September 2020 including original and review articles, systematic reviews and meta-analyses.

Growth hormone is crucial for the attainment of normal growth and for adequate somatic development, which does not end concomitantly with linear growth.

Who the Included Studies Covered

By PubMed's age tags, the people studied were children, teenagers and adults.

What Was Measured

Retesting adolescents who already meet the criteria that predict adult GHD with high specificity is not necessary.

Patients with isolated GHD have a high likelihood of normal response to GH testing after puberty.

Topics PubMed links to this paper include Growth Hormone, Human Growth Hormone, Insulin-Like Growth Factor I, Puberty, Quality of Life and Transition to Adult Care.

Author keywords: Adolescent, Growth and development, Hypopituitarism, Metabolism and Therapeutics.

What This Means in Plain Language

This is a review of Exogenous HGH, sermorelin & older GHRPs (why they're passed over).

Results are reported in around 2 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2021 (Jornal de pediatria), a journal based in Brazil.

More context: the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) compound page, all human trials.