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The effect of oral magnesium supplementation on acute non-specific low back pain: Prospective randomized clinical trial.
Plain-language guide to PMID 33812327 (2021): open-label randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 80 patients.
Key Facts
- PMID
- 33812327
- Journal
- The American journal of emergency medicine
- Year
- 2021
- Study type
- Randomized Controlled Trial
- Authors
- Bayram S et al. (7 authors)
- DOI
- 10.1016/j.ajem.2021.03.078
What This Study Did, in Plain Language
What Was Tested
Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.
The researchers aimed to investigate the effect of oral magnesium supplementation for acute low back pain.
Why It Was Studied
Level I, prospective randomized controlled study.
Who Took Part
The study group was 80 patients.
The age groups tagged for this paper are adults, both men and women.
This is a three-arm, prospective randomized open label clinical trial, which included two hundred and forty patients.
The researchers based their sample size calculation assumptions on a recently published clinical trial, thus the researchers enrolled 80 patients for each group.
How the Study Was Run
The researchers set it up as a randomized and open-label study.
The patients were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.
Everyone knew when Vitamin D, K2, Magnesium and Zinc was being given (open label), which is simpler to run but leaves more room for expectations to affect what is reported.
Follow-up visits after initiation of relevant treatment were performed at 4th and 10th days and outcome measures included pain (Visual analogue scale - VAS), mobility of lumbar spine and functional outcome (RMDQ).
What Was Measured
Level I, prospective randomized controlled study.
Topics PubMed links to this paper include Anti-Inflammatory Agents, Non-Steroidal, Dietary Supplements, Low Back Pain and Magnesium.
Author keywords: Acute low back pain, Non-steroid anti-inflammatory and Paracetamol.
What This Means in Plain Language
The paper is a randomized and open-label study of Vitamin D, K2, Magnesium and Zinc in 80 patients.
The abstract goes on to report its results in about 3 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2021 (The American journal of emergency medicine), a journal based in United States.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.