Impact of preimplantation genetic testing for aneuploidies (PGT-A) on first trimester biochemical markers - PAPP-A (placenta-associated plasma protein) and free β-hCG (human chorionic gonadotropin)

What Was Tested

Researchers studied hCG (human chorionic gonadotropin) in this observational study publication.

The objective of the study was to study the effect of preimplantation genetic testing for aneuploidies (PGT-A) performed at blastocyst stage on the levels of first trimester biomarkers.

Who Took Part

The study group was 143 patients.

PubMed tags the participants as women only.

Seven hundred and twenty-eight patients were included in the study.

Patients were with singleton pregnancies resulting from either natural conception (NC), or assisted reproductive techniques (ARTs) with PGT-A and frozen embryo transfer (FET) (ART/PGT-A/FET) or after ART without PGT-A and fresh ET (ART/no PGT-A/fresh ET) or FET (ART/no PGT-A/FET), who had first trimester combined screening test between 11 and 14 gestational weeks.

How the Study Was Run

This is an observational, collaborative, retrospective study.

They were stratified into four groups: group A (ART/PGT-A/FET) - 143 patients; group B (ART/no PGT-A/FET) - 100 patients; group C (ART/no PGT-A/fresh ET) - 346 patients, and group D (NC) - 139 patients.

What Was Measured

Topics PubMed links to this paper include Aneuploidy, Biomarkers, Blood Proteins, Chorionic Gonadotropin, Chorionic Gonadotropin, beta Subunit, Human, Genetic Testing and Placenta.

The authors tagged it with the keywords ART, PAPP-A, PGT-A, first trimester screening and free β-HCG.

What This Means in Plain Language

This is an observational study of hCG (human chorionic gonadotropin) in 143 patients.

Results are reported in around 12 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2022 (The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians), a journal based in England.

More context: the hCG (human chorionic gonadotropin) compound page, all human trials.