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Impact of daily-supervised administration of a package of iron and folic acid and vitamin B12 on hemoglobin levels among adolescent girls (12-19 years): a cluster randomized control trial.
Plain-language guide to PMID 33828241 (2021): randomized controlled trial of Cyanocobalamin (Vitamin B12) in 760 girls.
Key Facts
- PMID
- 33828241
- Journal
- European journal of clinical nutrition
- Year
- 2021
- Study type
- Randomized Controlled Trial
- Authors
- Gupta A et al. (7 authors)
- DOI
- 10.1038/s41430-021-00878-6
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Cyanocobalamin (Vitamin B12), published as a randomized controlled trial.
The prevalence of anemia has remained high among Indian adolescent girls over the past decade, despite the ongoing iron and folic acid (IFA) supplementation program.
Who Took Part
The abstract describes 760 girls taking part.
By PubMed's age tags, the people studied were children, teenagers, young adults and adults, women only.
A total of 760 adolescent girls in the age group of 12-19 years with mild and moderate anemia were selected from government schools.
How the Study Was Run
In design terms this was a randomized and placebo-controlled study.
Random assignment meant chance, not the researchers, decided who got Cyanocobalamin (Vitamin B12) and who got the comparison, which limits bias.
A placebo (an inactive look-alike) gave the Cyanocobalamin (Vitamin B12) group a baseline to be compared against.
A community-based cluster-randomized trial was conducted in the rural block of Faridabad District, Haryana, India in the year 2017.
Hemoglobin, serum ferritin, and vitamin B12 levels were assessed at baseline and endline.
What Was Measured
The subject headings attached to it are Anemia, Iron-Deficiency, Dietary Supplements, Folic Acid, Hemoglobins, Iron, Vitamin B 12 and Vitamins.
What This Means in Plain Language
The paper is a randomized and placebo-controlled study of Cyanocobalamin (Vitamin B12) in 760 girls.
With several hundred people or more, it is a fairly large study for this kind of research.
The abstract goes on to report its results in about 6 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2021 (European journal of clinical nutrition), a journal based in England.
More context: the Cyanocobalamin (Vitamin B12) compound page, all human trials.
Our Notes on the Compound
Cyanocobalamin (Vitamin B12): A synthetic form of vitamin B12 (cobalamin), an essential nutrient for DNA synthesis, red blood cell formation and neurological function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.