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Embryo Morphokinetics and Blastocyst Development After GnRH Agonist versus hCG Triggering in Normo-ovulatory Women: a Secondary Analysis of a Multicenter Randomized Controlled Trial
Plain-language guide to PMID 33847977 (2021): multicenter randomized controlled trial of hCG (human chorionic gonadotropin) in 216 women.
Key Facts
- PMID
- 33847977
- Journal
- Reproductive sciences (Thousand Oaks, Calif.)
- Year
- 2021
- Study type
- Randomized Controlled Trial
- Authors
- Alexopoulou E et al. (15 authors)
- DOI
- 10.1007/s43032-021-00564-9
What This Study Did, in Plain Language
What Was Tested
Researchers studied hCG (human chorionic gonadotropin) in this randomized controlled trial publication.
This study is a secondary analysis of a multicenter, randomized controlled trial, with the aim to compare embryo development in normo-ovulatory women, randomized to GnRHa or human chorionic gonadotropin (hCG) trigger.
A sub-analysis in 250 women enrolled at the main trial site including 2073 oocytes was conducted to compare embryo morphokinetics and cleavage patterns with EmbryoScope time-lapse system.
Why It Was Studied
However, less is known about the ovulation induction triggers effect on early embryo development and blastocyst formation.
In all, 4056 retrieved oocytes were observed, 1998 from the GnRHa group (216 women) and 2058 from the hCG group (218 women).
Who Took Part
The study group was 216 women.
The age groups tagged for this paper are adults, women only.
How the Study Was Run
In design terms this was a randomized and multicenter study.
Random assignment meant chance, not the researchers, decided who got hCG (human chorionic gonadotropin) and who got the comparison, which limits bias.
More than one site took part, so the women came from several places.
What Was Measured
PubMed files the paper under topics including Blastocyst, Chorionic Gonadotropin, Embryo Culture Techniques, Embryonic Development, Gonadotropin-Releasing Hormone, Ovulation and Ovulation Induction.
Author keywords: Blastocyst formation, Embryo development, GnRHa, Morphokinetiks, Ovulation trigger and hCG.
What This Means in Plain Language
The paper is a randomized and multicenter study of hCG (human chorionic gonadotropin) in 216 women.
The publication is from 2021 (Reproductive sciences (Thousand Oaks, Calif.)), a journal based in United States.
More context: the hCG (human chorionic gonadotropin) compound page, all human trials.
Our Notes on the Compound
hCG (human chorionic gonadotropin): An LH analog that drives Leydig-cell testosterone production.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.