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A closer look at alcohol-induced changes in the ghrelin system: novel insights from preclinical and clinical data
Plain-language guide to PMID 33908131 (2022): randomized controlled trial study of Ghrelin.
Key Facts
- PMID
- 33908131
- Journal
- Addiction biology
- Year
- 2022
- Study type
- Randomized Controlled Trial
- Authors
- Deschaine SL et al. (20 authors)
- DOI
- 10.1111/adb.13033
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial paper looks at Ghrelin.
To further characterize this relationship, the researchers examined (1) ghrelin levels via secondary analysis of human laboratory alcohol administration experiments with heavy-drinking participants; (2) expression of ghrelin, ghrelin receptor, and ghrelin-O-acyltransferase (GOAT) genes (GHRL, GHSR, and MBOAT4, respectively) in post-mortem brain tissue from individuals with alcohol use disorder (AUD) versus controls; (3) ghrelin levels in Ghsr knockout and wild-type rats following intraperitoneal (i.p.) alcohol administration; (4) effect of alcohol on ghrelin secretion from gastric mucosa cells ex vivo and GOAT enzymatic activity in vitro; and (5) ghrelin levels in rats following i.p. alcohol administration versus a calorically equivalent non-alcoholic sucrose solution.
Who Took Part
PubMed tags the participants as men only.
How the Study Was Run
In design terms this was a randomized study.
Random assignment meant chance, not the researchers, decided who got Ghrelin and who got the comparison, which limits bias.
What Was Measured
To further characterize this relationship, the researchers examined (1) ghrelin levels via secondary analysis of human laboratory alcohol administration experiments with heavy-drinking participants; (2) expression of ghrelin, ghrelin receptor, and ghrelin-O-acyltransferase (GOAT) genes (GHRL, GHSR, and MBOAT4, respectively) in post-mortem brain tissue from individuals with alcohol use disorder (AUD) versus controls; (3) ghrelin levels in Ghsr knockout and wild-type rats following intraperitoneal (i.p.) alcohol administration; (4) effect of alcohol on ghrelin secretion from gastric mucosa cells ex vivo and GOAT enzymatic activity in vitro; and (5) ghrelin levels in rats following i.p. alcohol administration versus a calorically equivalent non-alcoholic sucrose solution.
The subject headings attached to it are Blood Glucose, Ethanol, Ghrelin, Rats, Receptors, Ghrelin and Signal Transduction.
The authors tagged it with the keywords GOAT, acyl-ghrelin, alcohol, calorie and des-acyl-ghrelin.
What This Means in Plain Language
The paper is a randomized study of Ghrelin.
The publication is from 2022 (Addiction biology), a journal based in United States.
More context: the Ghrelin compound page, all human trials.
Our Notes on the Compound
Ghrelin: A 28-amino-acid stomach hormone that signals hunger and triggers growth hormone release; studied in human trials as an infusion.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.