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Maternal obesity and baseline vitamin D insufficiency alter the response to vitamin D supplementation: a double-blind, randomized trial in pregnant women.
Plain-language guide to PMID 33964855 (2021): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 240 women.
Key Facts
- PMID
- 33964855
- Journal
- The American journal of clinical nutrition
- Year
- 2021
- Study type
- Randomized Controlled Trial
- Authors
- Alhomaid RM et al. (7 authors)
- DOI
- 10.1093/ajcn/nqab112
- Registered trial
- NCT02713009
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.
The secondary aim was to investigate the influence of maternal BMI (in kg/m2) on the response of the primary outcomes.
Why It Was Studied
The achievement of target 25-hydroxyvitamin D [25(OH)D] concentrations in pregnancy may be altered by maternal obesity.
Who Took Part
The study group was 240 women.
PubMed indexes the participants as adults, women only.
The authors performed a 2-arm parallel double-blind randomized trial with 240 pregnant women recruited throughout the year in Northern Ireland.
A total of 166 women completed the study.
How the Study Was Run
The design is described as randomized, double-blind and parallel-group.
Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
Neither the women nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.
The Vitamin D, K2, Magnesium and Zinc group and the comparison group ran side by side rather than switching.
Maternal blood samples collected at 12, 28, and 36 GW and from the umbilical cord were analyzed for total serum 25(OH)D.
What Was Measured
The subject headings attached to it are Dietary Supplements, Fetal Blood, Pregnancy in Obesity, Vitamin D and Vitamin D Deficiency.
Author keywords: 25(OH)D concentration, BMI, body weight, maternal obesity and vitamin D requirements.
What This Means in Plain Language
The paper is a randomized, double-blind and parallel-group study of Vitamin D, K2, Magnesium and Zinc in 240 women.
Its findings take up roughly 6 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.
The publication is from 2021 (The American journal of clinical nutrition), a journal based in United States.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.