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The effect of early vasopressin use on patients with septic shock: A systematic review and meta-analysis.
Plain-language guide to PMID 33975132 (2021): meta-analysis of Vasopressin.
Key Facts
- PMID
- 33975132
- Journal
- The American journal of emergency medicine
- Year
- 2021
- Study type
- Meta-Analysis
- Authors
- Huang H et al. (6 authors)
- DOI
- 10.1016/j.ajem.2021.05.007
What This Paper Covers, in Plain Language
What It Covers
This meta-analysis looks at Vasopressin.
A systematic review and meta-analysis was performed to evaluate the impact of early start of vasopressin support within 6 h after the diagnosis on clinical outcomes in septic shock patients.
Why It Was Studied
The effect of early vasopressin initiation on clinical outcomes in patients with septic shock is uncertain.
Who the Included Studies Covered
The researchers included studies involving adult patients (> 16 years)with septic shock.
All authors reported their primary outcome of short-term mortality and in the experimental group patients in the studies receiving vasopressin infusion within 6 h after diagnosis of septic shock and in the control group patients in the studies receiving no vasopressin infusion or vasopressin infusion 6 h after diagnosis of septic shock, clearly comparing with clinically relevant secondary outcomes(use of renal replacement therapy(RRT),new onset arrhythmias, ICU length of stay and length of hospitalization).
How the Review Was Done
The researchers searched the PubMed, Cochrane, and Embase databases for randomized controlled trials (RCTs) and cohort studies from inception to the 1st of February 2021.
What Was Measured
The effect of early vasopressin initiation on clinical outcomes in patients with septic shock is uncertain.
The subject headings attached to it are Acute Kidney Injury, Arrhythmias, Cardiac, Early Medical Intervention, Intensive Care Units, Length of Stay, Mortality and Renal Replacement Therapy.
Author keywords: Meta-analysis, Septic shock, Systematic review and Vasopressin initiation.
What This Means in Plain Language
This is a meta-analysis of Vasopressin.
The abstract goes on to report its results in about 6 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2021 (The American journal of emergency medicine), a journal based in United States.
More context: the Vasopressin compound page, all human trials.
Our Notes on the Compound
Vasopressin: A 9-amino-acid hormone (antidiuretic hormone) that controls water balance and blood vessel tone; used in septic shock.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.