Effect of Vitamin D status on QTc interval in type 2 diabetes mellitus.

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as an observational study.

Vitamin D may also cause QTc prolongation.

The researchers hypothesized that concomitant Vitamin D deficiency and Type 2 DM may act in synergy to prolong QTc interval.

Who Took Part

According to the abstract, 2 patients were involved.

The age groups tagged for this paper are adults, middle-aged adults and older adults, both men and women.

Newly diagnosed Type 2 DM patients were recruited from Department of Endocrinology.

Patients were divided into two groups- Vitamin D deficient and insufficient (VDD/I) and optimal (VDO) as per standard criteria.

How the Study Was Run

Lead II ECG was acquired for 5 min during supine rest using a digital data acquisition system.

QTc interval extraction was performed using software. 25-hydroxy Vitamin D estimation was done using Chemiluminescence method.

QTc intervals were compared between the two groups.

What Was Measured

Topics PubMed links to this paper include Autonomic Nervous System, Blood Glucose, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Electrocardiography, Glycated Hemoglobin and Long QT Syndrome.

The authors tagged it with the keywords ECG, QT interval, type 2 diabetes and vitamin D.

What This Means in Plain Language

This is an observational study of Vitamin D, K2, Magnesium and Zinc in 2 patients.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

Its findings take up roughly 6 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2020 (Journal of basic and clinical physiology and pharmacology), a journal based in Germany.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.