A pilot-randomized, double-blind crossover trial to evaluate the pharmacokinetics of orally administered 25-hydroxyvitamin D3 and vitamin D3 in healthy adults with differing BMI and in adults with intestinal malabsorption.

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

Who Took Part

The study group was 6 patients.

PubMed indexes the participants as adults and middle-aged adults, both men and women.

How the Study Was Run

The design is described as randomized, double-blind, crossover and pilot.

The patients were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

Neither the patients nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.

In the crossover set-up each of the patients took both Vitamin D, K2, Magnesium and Zinc and the comparison in turn, acting as their own control.

It is described as a pilot, a small early test of whether a larger Vitamin D, K2, Magnesium and Zinc study would be practical.

For each PKS, serum vitamin D3 and 25(OH)D3 were measured at baseline and at 2, 4, 6, 8, and 12 h and days 1, 2, 3, 7, and 14.

What Was Measured

PubMed files the paper under topics including Area Under Curve, Body Mass Index, Calcifediol, Calcium-Regulating Hormones and Agents, Cholecalciferol, Half-Life and Malabsorption Syndromes.

The authors tagged it with the keywords 25-hydroxyvitamin D, bioavailability, clinical trial, intestinal malabsorption, obesity and vitamin D.

What This Means in Plain Language

The paper is a randomized, double-blind and crossover study of Vitamin D, K2, Magnesium and Zinc in 6 patients.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

Results are reported in around 7 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2021 (The American journal of clinical nutrition), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.