Impact of vitamin D status and cathelicidin antimicrobial peptide on adults with active pulmonary TB globally: A systematic review and meta-analysis.

What It Covers

This meta-analysis looks at LL-37 (cathelicidin) and Vitamin D, K2, Magnesium and Zinc.

This systematic review attempts to compare vitamin D andLL-37 levels among adult pulmonary tuberculosis patients to non-pulmonary TB individuals between 16-75 years globally and to determine the association between vitamin D and cathelicidin and any contributing factor among the two study groups.

Why It Was Studied

Tuberculosis remains a global threat and a public health problem that has eluded attempts to eradicate it.

Low vitamin D levels have been identified as a risk factor for tuberculosis infection and disease.

Who the Included Studies Covered

By PubMed's age tags, the people studied were teenagers, adults, middle-aged adults and older adults, both men and women.

How the Review Was Done

The researchers performed a search, through PubMed, HINARI, Google Scholar, EBSCOhost, and databases.

A narrative synthesis through evaluation of vitamin D and LL-37 levels, the association of vitamin D and LL-37, and other variables in individual primary studies were performed.

This protocol is registered under the International Prospective Register of Systematic Reviews (PROSPERO), registration number CRD42019127232.

What Was Measured

Low vitamin D levels have been identified as a risk factor for tuberculosis infection and disease.

The subject headings attached to it are Antimicrobial Cationic Peptides, Global Health, Tuberculosis, Pulmonary, Vitamin D, Vitamin D Deficiency and Cathelicidins.

What This Means in Plain Language

This is a meta-analysis of LL-37 (cathelicidin) and Vitamin D, K2, Magnesium and Zinc.

The abstract goes on to report its results in about 7 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2021 (PloS one), a journal based in United States.

More context: the LL-37 (cathelicidin) compound page and the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.