ACTH Stimulation Maximizes the Accuracy of Peripheral Steroid Profiling in Primary Aldosteronism Subtyping

What Was Tested

The paper reports a study of ACTH (Corticotropin) and Cosyntropin, published as a clinical trial.

To investigate plasma steroid differences between aldosterone-producing adenoma (APA) and bilateral PA (BPA) relative to ACTH variations.

Why It Was Studied

Dynamic manipulation of the hypothalamic-pituitary-adrenal (HPA) axis could assist PA subtyping, but a direct comparison of dynamic tests is lacking.

Who Took Part

The abstract describes 80 patients taking part.

The age groups tagged for this paper are adults, middle-aged adults and older adults, both men and women.

The researchers conducted comprehensive dynamic testing in 80 patients: 40 with APA and 40 with BPA.

The researchers quantified 17 steroids by mass spectrometry in response to ACTH variations in all patients and compared their discriminative power between the 2 PA subtypes.

What Was Measured

Dynamic manipulation of the hypothalamic-pituitary-adrenal (HPA) axis could assist PA subtyping, but a direct comparison of dynamic tests is lacking.

PubMed files the paper under topics including Adrenocorticotropic Hormone, Aldosterone, Cosyntropin, Diagnostic Techniques, Endocrine, Hydrocortisone, Hyperaldosteronism and Predictive Value of Tests.

The authors tagged it with the keywords ACTH, adrenal cortex, hypertension, mass spectrometry and primary aldosteronism.

What This Means in Plain Language

This is a clinical trial of ACTH (Corticotropin) and Cosyntropin in 80 patients.

The abstract goes on to report its results in about 5 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2021 (The Journal of clinical endocrinology and metabolism), a journal based in United States.

More context: the ACTH (Corticotropin) compound page and the Cosyntropin compound page, all human trials.