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Effect of vitamin D supplementation on total and allergen-specific IgE in children with asthma and low vitamin D levels.
Plain-language guide to PMID 34118248 (2022): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 174 participants.
Key Facts
- PMID
- 34118248
- Journal
- The Journal of allergy and clinical immunology
- Year
- 2022
- Study type
- Randomized Controlled Trial
- Authors
- Rosser FJ et al. (13 authors)
- DOI
- 10.1016/j.jaci.2021.05.037
What This Study Did, in Plain Language
What Was Tested
Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.
Observational studies have yielded inconsistent findings for the relation between vitamin D level and total IgE or allergic sensitization.
Who Took Part
According to the abstract, 174 participants were involved.
PubMed indexes the participants as children, both men and women.
Multivariable linear regression was used for the analysis of the effect of vitamin D supplementation on change in each IgE measure.
How the Study Was Run
The design is described as randomized, double-blind, placebo-controlled and multicenter.
Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.
Blinding on both sides kept the participants and researchers unaware of who received Vitamin D, K2, Magnesium and Zinc.
The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.
More than one site took part, so the participants came from several places.
What Was Measured
Observational studies have yielded inconsistent findings for the relation between vitamin D level and total IgE or allergic sensitization.
Topics PubMed links to this paper include Allergens, Antigens, Dermatophagoides, Arthropod Proteins, Asthma, Cysteine Endopeptidases, Dietary Supplements and Immunoglobulin E.
Author keywords: Vitamin D and children.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 174 participants.
Results are reported in around 4 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 2022 (The Journal of allergy and clinical immunology), a journal based in United States.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.