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Impact of Midregional N-Terminal Pro-Atrial Natriuretic Peptide and Soluble Suppression of Tumorigenicity 2 Levels on Heart Rhythm in Patients Treated With Catheter Ablation for Atrial Fibrillation: The Biorhythm Study
Plain-language guide to PMID 34187182 (2021): multicenter observational study of ANP (Atrial Natriuretic Peptide) in 106 patients.
Key Facts
- PMID
- 34187182
- Journal
- Journal of the American Heart Association
- Year
- 2021
- Study type
- Observational Study
- Authors
- Badoz M et al. (13 authors)
- DOI
- 10.1161/JAHA.121.020917
What This Study Did, in Plain Language
What Was Tested
This observational study looks at ANP (Atrial Natriuretic Peptide).
Background the researchers assessed the impact of preprocedural plasma levels of MRproANP (midregional N-terminal pro-atrial natriuretic peptide) and sST2 (soluble suppression of tumorigenicity 2) on recurrence of atrial fibrillation (AF) at 1 year after catheter ablation of AF.
Methods and Results This was a prospective, multicenter, observational study including patients undergoing catheter ablation of AF.
Who Took Part
According to the abstract, 106 patients were involved.
The age groups tagged for this paper are middle-aged adults and older adults, both men and women.
How the Study Was Run
In design terms this was a multicenter study.
More than one site took part, so the patients came from several places.
MRproANP and sST2 were measured in a peripheral venous blood preprocedure, and MRproANP was assessed in the right and left atrial blood during ablation.
What Was Measured
Background the researchers assessed the impact of preprocedural plasma levels of MRproANP (midregional N-terminal pro-atrial natriuretic peptide) and sST2 (soluble suppression of tumorigenicity 2) on recurrence of atrial fibrillation (AF) at 1 year after catheter ablation of AF.
The primary end point was recurrent AF between 3 and 12 months postablation, defined as a documented (>30 seconds) episode of AF, flutter, or atrial tachycardia.
Topics PubMed links to this paper include Atrial Fibrillation, Atrial Natriuretic Factor, Biomarkers, Catheter Ablation, France, Heart Atria and Heart Rate.
The authors tagged it with the keywords MRproANP and sST2.
What This Means in Plain Language
The paper is a multicenter study of ANP (Atrial Natriuretic Peptide) in 106 patients.
The publication is from 2021 (Journal of the American Heart Association), a journal based in England.
More context: the ANP (Atrial Natriuretic Peptide) compound page, all human trials.
Our Notes on the Compound
ANP (Atrial Natriuretic Peptide): A 28-amino-acid heart hormone that relaxes blood vessels and increases salt excretion; carperitide is a recombinant form.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.