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No effect of calcium and vitamin D intake on maternal blood pressure in a healthy pregnant population.
Plain-language guide to PMID 34271366 (2021): randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 415 women, low blood pressure and orthostatic hypotension.
Key Facts
- PMID
- 34271366
- Journal
- European journal of obstetrics, gynecology, and reproductive biology
- Year
- 2021
- Study type
- Randomized Controlled Trial
- Authors
- Forde H et al. (8 authors)
- DOI
- 10.1016/j.ejogrb.2021.07.005
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Vitamin D, K2, Magnesium and Zinc in the context of low blood pressure and orthostatic hypotension, published as a randomized controlled trial.
Clinical studies have reported an inverse relationship between calcium and vitamin D intake and hypertensive disorders of pregnancy (HDP).
The aim of this study was to investigate if there was an association between calcium/vitamin D intake, and vitamin D (25OHD) status, and maternal blood pressure (BP), during pregnancy and at 5-year follow-up.
Who Took Part
The abstract describes 415 women taking part.
PubMed tags the participants as women only.
Maternal BP measurements were taken during each trimester and at 5-year follow-up.
How the Study Was Run
The researchers set it up as a randomized study.
The women were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.
Calcium and vitamin D intake were determined at each trimester and 25OHD was measured in early and late pregnancy.
What Was Measured
Topics PubMed links to this paper include Blood Pressure, Calcium, Nutritional Status, Vitamin D and Vitamin D Deficiency.
Author keywords: Hypertensive disorders of pregnancy and Pre-eclampsia.
What This Means in Plain Language
The paper is a randomized study of Vitamin D, K2, Magnesium and Zinc in 415 women in people with low blood pressure and orthostatic hypotension.
With several hundred people or more, it is a fairly large study for this kind of research.
The abstract goes on to report its results in about 5 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2021 (European journal of obstetrics, gynecology, and reproductive biology), a journal based in Ireland.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, Low blood pressure and orthostatic hypotension research.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
- Low blood pressure and orthostatic hypotension research
- Vitamin D, K2, Magnesium and Zinc in the library
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.