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Male vitamin D status and male factor infertility.
Plain-language guide to PMID 34289935 (2021): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc.
Key Facts
- PMID
- 34289935
- Journal
- Fertility and sterility
- Year
- 2021
- Study type
- Randomized Controlled Trial
- Authors
- Banks N et al. (10 authors)
- DOI
- 10.1016/j.fertnstert.2021.06.035
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.
To determine the association between vitamin D levels in the male partner and fertility outcomes in couples with mild male factor infertility.
Who Took Part
PubMed indexes the participants as adults, both men and women.
Female partners were ovulatory, ≤40 years old, and had documented tubal patency.
Men provided semen and blood at baseline for semen analysis and 25-hydroxyvitamin D (25(OH)D) levels.
How the Study Was Run
In design terms this was a randomized, double-blind and placebo-controlled study.
Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.
Blinding on both sides kept the participants and researchers unaware of who received Vitamin D, K2, Magnesium and Zinc.
A placebo (an inactive look-alike) gave the Vitamin D, K2, Magnesium and Zinc group a baseline to be compared against.
Secondary analysis of a randomized, controlled trial.
Nine fertility centers in the United States.
Couples attempted to conceive naturally during the first 3 months and with clomiphene citrate with intrauterine insemination of the female partner in months 4 through 6.
What Was Measured
Topics PubMed links to this paper include Abortion, Spontaneous, Biomarkers, Clomiphene, Dietary Supplements, Fertility, Fertility Agents, Female and Infertility, Male.
The authors tagged it with the keywords 25-Hydroxyvitamin D, male factor infertility and vitamin D.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.
The abstract goes on to report its results in about 7 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2021 (Fertility and sterility), a journal based in United States.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.