Circulating adrenomedullin and B-type natriuretic peptide do not predict blood pressure fluctuations during pheochromocytoma resection: a cross-sectional study

What Was Tested

Researchers studied BNP (Nesiritide) and Adrenomedullin in the context of low blood pressure and orthostatic hypotension in this randomized controlled trial publication.

Despite adequate presurgical management, blood pressure fluctuations are common during resection of pheochromocytoma or sympathetic paraganglioma (PPGL).

To a large extent, the variability in blood pressure control during PPGL resection remains unexplained.

Who Took Part

By PubMed's age tags, the people studied were adults, middle-aged adults and older adults, both men and women.

Study subjects participated in PRESCRIPT, a randomized controlled trial in patients undergoing PPGL resection.

How the Study Was Run

The design is described as randomized.

Because people in this BNP (Nesiritide) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

MR-proADM and NT-proBNP were determined in a single plasma sample drawn before surgery.

Multivariable linear and logistic regression analyses were used to explore associations between these biomarkers and blood pressure fluctuations, use of vasoconstrictive agents during surgery as well as the occurrence of perioperative cardiovascular events.

What Was Measured

Adrenomedullin and B-type natriuretic peptide, measured as MR-proADM and NT-proBNP, respectively, are circulating biomarkers of cardiovascular dysfunction.

Topics PubMed links to this paper include Adrenal Gland Neoplasms, Adrenergic Antagonists, Adrenomedullin, Biomarkers, Blood Pressure, Cardiovascular Diseases and Cross-Sectional Studies.

What This Means in Plain Language

The paper is a randomized study of BNP (Nesiritide) and Adrenomedullin in people with low blood pressure and orthostatic hypotension.

Its findings take up roughly 7 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2021 (European journal of endocrinology), a journal based in England.

More context: the BNP (Nesiritide) compound page and the Adrenomedullin compound page, Low blood pressure and orthostatic hypotension research.