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Endometrial preparation for vitrified-warmed embryo transfer with or without GnRH-agonist pre-treatment in patients with polycystic ovary syndrome: a randomized controlled trial.
Plain-language guide to PMID 34340936 (2021): randomized controlled trial of Gonadorelin in 212 patients, endometriosis.
Key Facts
- PMID
- 34340936
- Journal
- Reproductive biomedicine online
- Year
- 2021
- Study type
- Randomized Controlled Trial
- Authors
- Salemi S et al. (4 authors)
- DOI
- 10.1016/j.rbmo.2021.06.006
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Gonadorelin in the context of endometriosis, published as a randomized controlled trial.
What are the effects on pregnancy outcome in patients with polycystic ovary syndrome (PCOS) in endometrial preparation cycles for vitrified-warmed embryo transfer with or without gonadotrophin releasing hormone (GnRH) agonist pre-treatment?
Who Took Part
According to the abstract, 212 patients were involved.
PubMed indexes the participants as adults, both men and women.
A total of 212 patients with PCOS referred to Royan Institute, Tehran, Iran, between 20 August 2017 to 20 June 2018 were included.
The patients were randomly assigned to receive oestradiol after downregulation with GnRH agonist (group A) or without GnRH agonist down-regulation (group B).
How the Study Was Run
The researchers set it up as a randomized study.
Because people in this Gonadorelin study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
What Was Measured
What are the effects on pregnancy outcome in patients with polycystic ovary syndrome (PCOS) in endometrial preparation cycles for vitrified-warmed embryo transfer with or without gonadotrophin releasing hormone (GnRH) agonist pre-treatment?
PubMed files the paper under topics including Embryo Implantation, Embryo Transfer, Endometrium, Fertility Agents, Female, Fertilization in Vitro, Gonadotropin-Releasing Hormone and Infertility, Female.
The authors tagged it with the keywords Endometrial preparation, FET cycles, GnRH agonist and PCOS.
What This Means in Plain Language
The paper is a randomized study of Gonadorelin in 212 patients in people with endometriosis.
The abstract goes on to report its results in about 5 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2021 (Reproductive biomedicine online), a journal based in Netherlands.
More context: the Gonadorelin compound page, Endometriosis research.
Our Notes on the Compound
Gonadorelin: A synthetic version of gonadotropin-releasing hormone (GnRH), the signal that tells the pituitary to release LH and FSH.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.