Vitamin D deficiency is a risk factor for new fractures in Japanese postmenopausal women with rheumatoid arthritis: results from the IORRA cohort study.

Plain-language guide to PMID 34342724 (2021): observational study of Vitamin D, K2, Magnesium and Zinc in 2567 patients, rheumatoid arthritis.

Key Facts

PMID: 34342724
Journal: Archives of osteoporosis
Year: 2021
Study type: Observational Study
Authors: Nakayama M et al. (7 authors)
DOI: 10.1007/s11657-021-00982-x

What This Study Did, in Plain Language

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in the context of rheumatoid arthritis in this observational study publication.

Both rheumatoid arthritis (RA) and menopause are known risk factors for the onset of osteoporosis.

The purpose of this study was to investigate whether vitamin D deficiency in Japanese women with RA could be a risk factor for new fractures.

Why It Was Studied

In this study, the researchers assess the association between the occurrence of new fractures and vitamin D deficiency in Japanese patients with rheumatoid arthritis using their large IORRA cohort.

Who Took Part

According to the abstract, 2567 patients were involved.

By PubMed's age tags, the people studied were middle-aged adults and older adults, women only.

Between 2011 and 2017, a total of 2567 female patients with RA over the age of 50 years (mean age, 65.9 years) were enrolled in a prospective observational study.

Self-reported occurrences of new fractures were verified using patient medical records.

How the Study Was Run

Vitamin D deficiency was defined as serum 25(OH)D levels < 20 ng/mL.

What Was Measured

In this study, the researchers assess the association between the occurrence of new fractures and vitamin D deficiency in Japanese patients with rheumatoid arthritis using their large IORRA cohort.

PubMed files the paper under topics including Arthritis, Rheumatoid, Cohort Studies, Japan, Osteoporotic Fractures, Postmenopause, Quality of Life and Risk Factors.

Author keywords: Japanese, Medication, Osteoporosis, Rheumatoid arthritis and Vitamin D deficiency.

What This Means in Plain Language

This is an observational study of Vitamin D, K2, Magnesium and Zinc in 2567 patients in people with rheumatoid arthritis.

With several hundred people or more, it is a fairly large study for this kind of research.

The abstract goes on to report its results in about 6 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2021 (Archives of osteoporosis), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, Rheumatoid arthritis research.

Our Notes on the Compound

Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.