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Cobalamin and folate status in women during early pregnancy in Bhaktapur, Nepal.
Plain-language guide to PMID 34422259 (2021): randomized controlled trial of Cyanocobalamin (Vitamin B12) in 561 women.
Key Facts
- PMID
- 34422259
- Journal
- Journal of nutritional science
- Year
- 2021
- Study type
- Randomized Controlled Trial
- Authors
- Schwinger C et al. (12 authors)
- DOI
- 10.1017/jns.2021.53
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Cyanocobalamin (Vitamin B12), published as a randomized controlled trial.
Yet, the status of these micronutrients is unknown in many populations.
The researchers assessed the concentration of cobalamin, folate and their functional biomarkers, total homocysteine (tHcy) and methylmalonic acid (MMA), in 561 pregnant women enrolled in a community-based randomised controlled trial in Bhaktapur, Nepal.
Who Took Part
The abstract describes 561 women taking part.
PubMed tags the participants as women only.
How the Study Was Run
In design terms this was a randomized study.
The women were allocated by chance, so the Cyanocobalamin (Vitamin B12) group and the comparison group should start out alike.
Plasma concentrations of cobalamin, folate, tHcy and MMA were measured and a combined indicator of vitamin B12 status (3cB12) was calculated.
What Was Measured
The researchers assessed the concentration of cobalamin, folate and their functional biomarkers, total homocysteine (tHcy) and methylmalonic acid (MMA), in 561 pregnant women enrolled in a community-based randomised controlled trial in Bhaktapur, Nepal.
The researchers report mean or median concentrations and the prevalence of deficiency according to commonly used cut-offs, and assessed their association with indicators of socio-economic status, and maternal and dietary characteristics by linear regression.
PubMed files the paper under topics including Folic Acid, Homocysteine, Methylmalonic Acid, Nepal, Vitamin B 12 and Vitamin B 12 Deficiency.
Author keywords: Asia, Low-income country, Micronutrient malnutrition, Nutritional status and Vitamin B12.
What This Means in Plain Language
The paper is a randomized study of Cyanocobalamin (Vitamin B12) in 561 women.
With several hundred people or more, it is a fairly large study for this kind of research.
The publication is from 2021 (Journal of nutritional science), a journal based in England.
More context: the Cyanocobalamin (Vitamin B12) compound page, all human trials.
Our Notes on the Compound
Cyanocobalamin (Vitamin B12): A synthetic form of vitamin B12 (cobalamin), an essential nutrient for DNA synthesis, red blood cell formation and neurological function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.