Impact of body mass index on growth hormone stimulation tests in children and adolescents: a systematic review and meta-analysis.

What It Covers

The paper reports a study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over), published as a meta-analysis.

In addition, exploratory moderator analyses and meta-regressions were performed to investigate the effects of sex, pubertal status, presence of syndromic obesity, mean age and mean BMI SDS on the study level.

Why It Was Studied

However, current guidelines do not guide how to interpret the peak GH values of these children.

This systematic review was performed by the PRISMA guidelines.

Who the Included Studies Covered

The age groups tagged for this paper are children and teenagers, men only.

In total, 58 studies were included, providing data on n = 5135 children (576 with individual participant data).

How the Review Was Done

Quality and risk of bias were evaluated using the Scottish Intercollegiate Guidelines Network (SIGN) checklists.

What Was Measured

The primary outcome was the association between peak GH values and BMI SDS.

For the individual participant dataset, linear mixed-models regression analysis was performed with BMI SDS as the predictor and ln(peak GH) as the outcome, accounting for the different studies and GH stimulation agents used.

Topics PubMed links to this paper include Body Mass Index, Human Growth Hormone, Obesity and Overdiagnosis.

The authors tagged it with the keywords Pediatric obesity, cutoff, diagnostic test and growth hormone deficiency.

What This Means in Plain Language

This is a meta-analysis of Exogenous HGH, sermorelin & older GHRPs (why they're passed over).

The publication is from 2021 (Critical reviews in clinical laboratory sciences), a journal based in England.

More context: the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) compound page, all human trials.