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Supraphysiological effects of pancreatic polypeptide on gastric motor function and nutrient tolerance in humans
Plain-language guide to PMID 34435472 (2021): single-blind randomized controlled trial study of Pancreatic Polypeptide in 12 volunteers.
Key Facts
- PMID
- 34435472
- Journal
- Physiological reports
- Year
- 2021
- Study type
- Randomized Controlled Trial
- Authors
- Verbeure W et al. (5 authors)
- DOI
- 10.14814/phy2.15002
What This Study Did, in Plain Language
What Was Tested
Researchers studied Pancreatic Polypeptide in this randomized controlled trial publication.
In this exploratory study, the researchers set out to investigate its supraphysiological effect on food tolerance, gastric accommodation, and emptying.
Why It Was Studied
Pancreatic polypeptide (PP) is known to affect food intake.
In a separate test, the effect of PP0 or PP10 on gastric emptying was tested in 10 healthy volunteers and assessed using the 13 C breath test.
Who Took Part
According to the abstract, 12 volunteers were involved.
How the Study Was Run
The researchers set it up as a randomized, single-blind and crossover study.
Because people in this Pancreatic Polypeptide study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
In this single-blind Pancreatic Polypeptide study one party knew the assignments and the other did not.
Each person switched between Pancreatic Polypeptide and the comparison at some point, usually with a gap in between.
Gastric accommodation was assessed by measuring the intragastric pressure (IGP; nasogastric manometry).
What Was Measured
In a separate test, the effect of PP0 or PP10 on gastric emptying was tested in 10 healthy volunteers and assessed using the 13 C breath test.
Topics PubMed links to this paper include Fasting, Gastric Emptying, Manometry, Nutrients, Pancreatic Polypeptide, Protein Precursors and Satiation.
Author keywords: food tolerance and gastric accommodation.
What This Means in Plain Language
The paper is a randomized, single-blind and crossover study of Pancreatic Polypeptide in 12 volunteers.
With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.
The publication is from 2021 (Physiological reports), a journal based in United States.
More context: the Pancreatic Polypeptide compound page, all human trials.
Our Notes on the Compound
Pancreatic Polypeptide: A 36-amino-acid pancreatic hormone in the same family as peptide YY and neuropeptide Y.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.