Intravenous magnesium sulfate for prevention of vancomycin plus piperacillin-tazobactam induced acute kidney injury in critically ill patients: An open-label, placebo-controlled, randomized clinical trial.

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.

Who Took Part

The abstract describes 72 adults taking part.

PubMed indexes the participants as middle-aged adults and older adults, both men and women.

In an open-label, placebo-controlled, randomized clinical trial, 72 adults (≥ 18 years old) who had indications to receive VPT as empiric therapy were assigned to the magnesium or control group in 1:1 ratio.

Concomitant with VPT, intravenous infusion of magnesium sulfate was started for patients in the magnesium group.

How the Study Was Run

The researchers set it up as a randomized, open-label and placebo-controlled study.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Nothing was hidden in this open-label Vitamin D, K2, Magnesium and Zinc study: the adults and staff both knew the treatment.

Some adults received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.

Patients in the control group received normal saline as placebo.

The study's primary outcome was incidence of AKI during and up to 48 h after the treatment course.

Escalation and de-escalation of VPT regimen, duration of hospitalization, length of ICU stay and 28-day mortality were secondary outcomes.

What Was Measured

The subject headings attached to it are Acute Kidney Injury, Administration, Intravenous, Critical Illness, Incidence, Length of Stay, Logistic Models and Magnesium Sulfate.

The authors tagged it with the keywords Piperacillin-tazobactam and Vancomycin.

What This Means in Plain Language

The paper is a randomized, open-label and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 72 adults.

The abstract goes on to report its results in about 7 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2021 (Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences), a journal based in Switzerland.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.