Low vitamin D exposure and risk of nasopharyngeal carcinoma: Observational and genetic evidence from a multicenter case-control study.

What Was Tested

This observational study looks at Vitamin D, K2, Magnesium and Zinc.

Little is known about the risk of nasopharyngeal carcinoma (NPC) in relation to vitamin D exposure.

The aim of this study was to examine the associations of NPC risk with serum level of 25-hydroxyvitamin D (25OHD) and genetic predicted 25OHD, and potential effect modification by several putative risk factors of NPC.

Who Took Part

The study group was 299 subjects.

The age groups tagged for this paper are middle-aged adults, both men and women.

Their multicenter case-control study in Hong Kong recruited 815 NPC cases and 1502 frequency-matched (by sex and age) hospital controls from five major regional hospitals, and recruited 299 healthy subjects from blood donation centers (2014-2017).

How the Study Was Run

The design is described as multicenter.

More than one site took part, so the subjects came from several places.

Circulating level of 25-hydroxyvitamin D (25OHD) and genetic predicted 25OHD (rs12785878, rs11234027, rs12794714, rs4588 and rs6013897) were measured by validated enzyme immunoassay and the iPLEX assay on the MassARRAY System, respectively.

Data were also collected on demographics, lifestyle factors, ultraviolet radiation exposure, and potential confounders using a computer-assisted, self-administered questionnaire with satisfactory test-retest reliability.

What Was Measured

PubMed files the paper under topics including Body Mass Index, Case-Control Studies, Early Detection of Cancer, Genetic Predisposition to Disease, Hong Kong, Logistic Models and Nasopharyngeal Carcinoma.

Author keywords: 25-Hydroxyvitamin D, Epidemiology, Genetic variant and Vitamin D deficiency.

What This Means in Plain Language

The paper is a multicenter study of Vitamin D, K2, Magnesium and Zinc in 299 subjects.

Results are reported in around 4 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2021 (Clinical nutrition (Edinburgh, Scotland)), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.