Effect of omega-3 and vitamin D co-supplementation on psychological distress in reproductive-aged women with pre-diabetes and hypovitaminosis D: A randomized controlled trial.

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

Psychological distresses and pre-diabetes are among the risk factors of developing type-II diabetes.

Why It Was Studied

Iranian Registry of Clinical Trials Code: IRCT20100130003226N17.

Registered on February 9, 2019.

Who Took Part

According to the abstract, 168 women were involved.

PubMed indexes the participants as adults, women only.

The present factorial clinical trial was conducted on 168 women of reproductive age with pre-diabetes and hypovitaminosis D.

The Depression Anxiety Stress Scale-21 and the Pittsburgh Sleep Quality Index were completed by the participants at the start and end of the intervention.

How the Study Was Run

In design terms this was a randomized, double-blind and placebo-controlled study.

The women were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

Neither the women nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.

The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.

Fasting blood glucose and vitamin D were measured at the beginning of the study.

What Was Measured

PubMed files the paper under topics including Dietary Supplements, Iran, Prediabetic State, Psychological Distress, Sleep Quality, Vitamin D and Vitamin D Deficiency.

The authors tagged it with the keywords anxiety, depression and omega-3 fatty acids.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 168 women.

Results are reported in around 4 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2021 (Brain and behavior), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.