Patterns of Bone Mineral Accretion and Sex Differences in Healthy Term Vitamin D Replete and Breastfed Infants From Montreal, Canada: Bone Mass Reference Data.

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.

The purpose of this report is to generate reference data for bone mass in breastfed vitamin D replete infants and investigate patterns of bone mineral accretion and sex differences.

Why It Was Studied

Infancy is a period of rapid bone growth and mineral accretion; nonetheless, reference data remain scarce for this age group.

This is a secondary analysis from a double-blinded randomized controlled trial (NCT00381914).

Who Took Part

According to the abstract, 63 infants were involved.

By PubMed's age tags, the people studied were infants, both men and women.

Plasma 25-hydroxyvitamin D (LC-MS/MS), bone mineral content (BMC; whole body (WB) and lumbar spine (LS)) and bone mineral density (BMD; LS) were measured at 1, 3, 6, 9, and 12 mo by dual-energy x-ray absorptiometry (Hologic Discovery 4500A) with no effect of supplementation on bone outcomes.

How the Study Was Run

The design is described as randomized and double-blind.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.

What Was Measured

This is a secondary analysis from a double-blinded randomized controlled trial (NCT00381914).

Differences over time and between sexes were tested using mixed model repeated measures ANOVA.

The subject headings attached to it are Absorptiometry, Photon, Bone Density, Breast Feeding, Canada, Chromatography, Liquid, Minerals and Sex Characteristics.

The authors tagged it with the keywords Bone mineral content, Bone mineral density, DXA and Infancy.

What This Means in Plain Language

The paper is a randomized and double-blind study of Vitamin D, K2, Magnesium and Zinc in 63 infants.

The publication is from 2022 (Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.