Serum Vitamin D: Correlates of Baseline Concentration and Response to Supplementation in VITAL-DKD.

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.

To assess the total serum vitamin D response to vitamin D3 supplementation and whether it varies according to participant characteristics.

To compare results with corresponding results for total serum 25-hydroxyvitamin D [25(OH)D], which is used clinically and measured in supplementation trials.

Who Took Part

The abstract describes 161 adults taking part.

PubMed indexes the participants as middle-aged adults and older adults, both men and women.

How the Study Was Run

The researchers set it up as a randomized and placebo-controlled study.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.

Exploratory study within a randomized trial.

What Was Measured

PubMed files the paper under topics including Cholecalciferol, Diabetes Mellitus, Type 2, Diabetic Nephropathies, Dietary Supplements, Fatty Acids, Omega-3, Vitamin D and Vitamin D Deficiency.

The authors tagged it with the keywords 25-hydroxyvitamin D, biomarkers and liquid chromatography-tandem mass spectrometry.

What This Means in Plain Language

The paper is a randomized and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 161 adults.

The abstract goes on to report its results in about 5 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2022 (The Journal of clinical endocrinology and metabolism), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.