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Salivary ghrelin response to drinks varying in protein content and quantity and association with energy intake and appetite
Plain-language guide to PMID 34653498 (2021): double-blind randomized controlled trial study of Ghrelin.
Key Facts
- PMID
- 34653498
- Journal
- Physiology & behavior
- Year
- 2021
- Study type
- Randomized Controlled Trial
- Authors
- Crabtree DR et al. (6 authors)
- DOI
- 10.1016/j.physbeh.2021.113622
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Ghrelin, published as a randomized controlled trial.
The primary aim of this study was to compare salivary and plasma ghrelin responses to dairy breakfast drinks varying in protein content and quantity, and to determine the relationship between salivary ghrelin and EI and appetite.
Why It Was Studied
Salivary hormone analysis is a non-invasive alternative to blood-borne hormone analysis.
The orexigenic hormone ghrelin has been detected in human saliva, though the relationship between salivary and blood-borne ghrelin and salivary ghrelin's association with energy intake (EI) and appetite remains unclear.
Who Took Part
PubMed indexes the participants as adults.
How the Study Was Run
The design is described as randomized, double-blind and crossover.
Because people in this Ghrelin study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
As a double-blind Ghrelin study, the assignments were hidden from both participants and investigators until the end.
Each person switched between Ghrelin and the comparison at some point, usually with a gap in between.
Salivary and plasma total ghrelin were measured at 0, 30, 60 and 120 min and appetite perceptions at 0, 30, 60, 90 and 120 min.
What Was Measured
Participants (n = 25) consumed four test drinks, varying in protein content and quantity, on four separate days in a double-blind randomized controlled study.
A buffet-style test meal was presented at 120 min to measure ad libitum EI.
Topics PubMed links to this paper include Appetite, Energy Intake, Ghrelin, Meals and Postprandial Period.
The authors tagged it with the keywords Protein and Saliva.
What This Means in Plain Language
The paper is a randomized, double-blind and crossover study of Ghrelin.
The publication is from 2021 (Physiology & behavior), a journal based in United States.
More context: the Ghrelin compound page, all human trials.
Our Notes on the Compound
Ghrelin: A 28-amino-acid stomach hormone that signals hunger and triggers growth hormone release; studied in human trials as an infusion.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.