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Vitamin D supplementation reduces the risk of fall in the vitamin D deficient elderly: An updated meta-analysis.

Plain-language guide to PMID 34656949 (2021): meta-analysis of Vitamin D, K2, Magnesium and Zinc.

Key Facts

PMID
34656949
Journal
Clinical nutrition (Edinburgh, Scotland)
Year
2021
Study type
Meta-Analysis
Authors
Ling Y et al. (8 authors)
DOI
10.1016/j.clnu.2021.09.031

What This Paper Covers, in Plain Language

What It Covers

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a meta-analysis.

However, considerable controversy exists regarding the association of such supplementation and fall risk.

Furthermore, some studies published recently were not included in the previous meta-analyses.

Who the Included Studies Covered

The age groups tagged for this paper are older adults and people over 80, both men and women.

Randomized clinical trials (RCTs) reporting the effect of vitamin D supplementation alone or with calcium on fall incidence were selected from studies.

How the Review Was Done

The researchers systematically searched several literature databases including PubMed and the Embase from inception to September 2020.

The protocol for this meta-analysis was registered with PROSPERO (CRD42021226380).

Qualitative and quantitative information was extracted; the random-effects model was conducted to pool the data for fall; statistical heterogeneity was assessed using the I2 test and potential for publication bias was assessed qualitatively by a visual estimate of the funnel plot and quantitatively by calculation of the Begg's test and the Egger's test.

What Was Measured

PubMed files the paper under topics including Accidental Falls, Dietary Supplements, Vitamin D, Vitamin D Deficiency and Vitamins.

Author keywords: Calcium, Meta-analysis and Randomized-controlled trials.

What This Means in Plain Language

This is a meta-analysis of Vitamin D, K2, Magnesium and Zinc.

The abstract goes on to report its results in about 7 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2021 (Clinical nutrition (Edinburgh, Scotland)), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.

Our Notes on the Compound

Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.

Related Pages

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.