Relationship of maternal obesity and vitamin D concentrations with fetal growth in early pregnancy.

What Was Tested

This clinical trial looks at Vitamin D, K2, Magnesium and Zinc.

Multivariate logistic regression was used to evaluate the association between maternal serum 25(OH)D levels and prepregnancy BMI with first trimester CRL and early FGR.

Who Took Part

The abstract describes 15,651 women taking part.

PubMed indexes the participants as children, women only.

This retrospective cohort study included 15,651 women with singleton pregnancy who delivered at the International Peace Maternity and Child Health Hospital between January 2015 and November 2016.

Women were classified in two groups based on their serum 25(OH)D vitamin levels status: VitD sufficient (SUFF) group and VitD insufficient or deficient (INSUFF/DEF).

How the Study Was Run

Comparisons were made between women with normal prepregnancy body weight (BMI 18.5-23.9 kg/m2) and overweight and obese (OWO) women (BMI > 24.0 kg/m2).

Early FGR was defined as first-trimester gestational age-adjusted crown-rump length (CRL) in the lowest 20th centile of the population.

What Was Measured

Topics PubMed links to this paper include Fetal Development, Fetal Growth Retardation, Pregnancy in Obesity, Vitamin D and Vitamins.

The authors tagged it with the keywords Crown-rump length, Early fetal growth restriction and Obesity in pregnancy.

What This Means in Plain Language

This is a clinical trial of Vitamin D, K2, Magnesium and Zinc in 15,651 women.

With several hundred people or more, it is a fairly large study for this kind of research.

The abstract goes on to report its results in about 5 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2022 (European journal of nutrition), a journal based in Germany.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.