Individual participant data (IPD)-level meta-analysis of randomised controlled trials to estimate the vitamin D dietary requirements in dark-skinned individuals resident at high latitude.

What It Covers

This meta-analysis looks at Vitamin D, K2, Magnesium and Zinc.

There is an urgent need to develop vitamin D dietary recommendations for dark-skinned populations resident at high latitude.

Using data from randomised controlled trials (RCTs) with vitamin D3-supplements/fortified foods, the researchers undertook an individual participant data-level meta-regression (IPD) analysis of the response of wintertime serum 25-hydroxyvitamin (25(OH)D) to total vitamin D intake among dark-skinned children and adults residing at ≥ 40° N and derived dietary requirement values for vitamin D.

Why It Was Studied

PROSPERO International Prospective Register of Systematic Reviews (Registration Number: CRD42018097260).

Who the Included Studies Covered

PubMed indexes the participants as young children, children, teenagers, young adults, adults, middle-aged adults, older adults and people over 80.

IPD analysis using data from 677 dark-skinned participants (of Black or South Asian descent; ages 5-86 years) in 10 RCTs with vitamin D supplements/fortified foods identified via a systematic review and predefined eligibility criteria.

How the Review Was Done

Outcome measures were vitamin D intake estimates across a range of 25(OH)D thresholds.

What Was Measured

The subject headings attached to it are Dietary Supplements, Nutritional Requirements, Seasons, Vitamin D, Vitamin D Deficiency and Vitamins.

Author keywords: Dark-skinned, Dietary reference values, Individual participant data-level meta-regression analyses, Recommended dietary allowance and Vitamin D recommendations.

What This Means in Plain Language

This is a meta-analysis of Vitamin D, K2, Magnesium and Zinc.

Its findings take up roughly 7 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2022 (European journal of nutrition), a journal based in Germany.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.