Effect of L-Carnitine Supplementation on Inflammatory Markers and Serum Glucose in Hemodialysis Children: A Randomized, Placebo-Controlled Clinical Trial

What Was Tested

Researchers studied L-Carnitine in this randomized controlled trial publication.

In addition, change in glucose metabolism is another common problem among CKD population.

Moreover, the one-way repeated measures analysis was used to evaluate the effects of L-carnitine supplementation.

Who Took Part

The abstract describes 12 patients taking part.

By PubMed's age tags, the people studied were children and teenagers, both men and women.

Twenty-four children on hemodialysis (aged between 6 and 18 years) were enrolled in this randomized clinical trial study.

How the Study Was Run

The researchers set it up as a randomized and placebo-controlled study.

The patients were allocated by chance, so the L-Carnitine group and the comparison group should start out alike.

The comparison arm used a placebo, so changes seen with L-Carnitine could be set against what happens without it.

The timeline in the abstract includes 10 weeks.

Afterward, the researchers determined serum FC, interleukin-6 (IL-6), high-sensitivity C-reactive protein, FBS, and albumin and Pediatrics Quality of Life scores once at the baseline and once after performing intervention for 10 weeks.

What Was Measured

Topics PubMed links to this paper include Albumins, Biomarkers, Blood Glucose, C-Reactive Protein, Carnitine, Dietary Supplements and Inflammation.

What This Means in Plain Language

The paper is a randomized and placebo-controlled study of L-Carnitine in 12 patients over 10 weeks.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

Its findings take up roughly 5 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2022 (Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation), a journal based in United States.

More context: the L-Carnitine compound page.