Tart Cherry Supplement Enhances Skeletal Muscle Glutathione Peroxidase Expression and Functional Recovery after Muscle Damage.

What Was Tested

This clinical trial looks at Glutathione and Copper (Supplement).

This study is the first to investigate functional recovery from exercise alongside molecular changes within the exercised muscle after MCC supplementation.

Why It Was Studied

Montmorency cherry concentrate (MCC) supplementation enhances functional recovery from exercise, potentially due to antioxidant and anti-inflammatory effects.

However, to date, supporting empirical evidence for these mechanistic hypotheses is reliant on indirect blood biomarkers.

Who Took Part

Ten participants completed two maximal unilateral eccentric knee extension trials after MCC or placebo (PLA) supplementation for 7 d before and 48 h after exercise.

How the Study Was Run

The design is described as double-blind and placebo-controlled.

Blinding on both sides kept the participants and researchers unaware of who received Glutathione.

A placebo (an inactive look-alike) gave the Glutathione group a baseline to be compared against.

Knee extension maximum voluntary contractions, maximal isokinetic contractions, single leg jumps, and soreness measures were assessed before, immediately, 24 h, and 48 h after exercise.

Venous blood and vastus lateralis muscle samples were collected at each time point.

Plasma concentrations of interleukin-6, tumor necrosis factor alpha, C-reactive protein, creatine kinase, and phenolic acids were quantified.

Intramuscular mRNA expressions of superoxide dismutase 1 (SOD1), SOD3, glutathione peroxidase 1 (GPX1), GPX3, GPX4, GPX7, catalase, and nuclear factor erythroid 2-related factor 2 and relative intramuscular protein expressions of SOD1, catalase, and GPX3 were quantified.

What Was Measured

Topics PubMed links to this paper include Antioxidants, Catalase, Dietary Supplements, Glutathione Peroxidase, Muscle, Skeletal, Myalgia and Polyesters.

What This Means in Plain Language

The paper is a double-blind and placebo-controlled study of Glutathione and Copper (Supplement).

Its findings take up roughly 4 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2022 (Medicine and science in sports and exercise), a journal based in United States.

More context: the Glutathione compound page and the Copper (Supplement) compound page, all human trials.