Effect of Intra Uterine Granulocyte Colony Stimulating Factor vs. Human Chorionic Gonadotropin at Ovum Pick Up Day on Pregnancy Rate in IVF/ICSI Cases With Recurrent Implantation Failure.

What Was Tested

Researchers studied hCG (human chorionic gonadotropin) in this randomized controlled trial publication.

Recurrent implantation failure is defined as failure to achieve clinical pregnancy after the transfer of four or more good-quality embryos in a minimum of three fresh or frozen cycles in a woman aged less than 40 years.

The objective is to compare between the effect of intrauterine G-CSF, hCG, and saline solution injection (as placebo) at the day of ovum pick-up on clinical pregnancy, chemical pregnancy, implantation, and miscarriage rates in patients with recurrent implantation failure undergoing IVF/ICSI.

Who Took Part

The study group was 150 patients.

PubMed tags the participants as women only.

This prospective, double blind, parallel, randomized controlled trial included 150 patients equally divided into 3 groups, each containing 50 individuals.

How the Study Was Run

The researchers set it up as a randomized, double-blind, placebo-controlled and parallel-group study.

Random assignment meant chance, not the researchers, decided who got hCG (human chorionic gonadotropin) and who got the comparison, which limits bias.

Blinding on both sides kept the patients and researchers unaware of who received hCG (human chorionic gonadotropin).

A placebo (an inactive look-alike) gave the hCG (human chorionic gonadotropin) group a baseline to be compared against.

The hCG (human chorionic gonadotropin) group and the comparison group ran side by side rather than switching.

The primary outcome measure is clinical pregnancy rate.

Secondary outcomes are biochemical pregnancy, implantation, and miscarriage rates.

What Was Measured

Topics PubMed links to this paper include Abortion, Spontaneous, Chorionic Gonadotropin, Embryo Transfer, Fertilization in Vitro, Granulocyte Colony-Stimulating Factor, Pregnancy Rate and Saline Solution.

Author keywords: G-CSF, clinical pregnancy, hCG, intrauterine injection and ovum pick-up.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of hCG (human chorionic gonadotropin) in 150 patients.

Its findings take up roughly 3 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2022 (JBRA assisted reproduction), a journal based in Brazil.

More context: the hCG (human chorionic gonadotropin) compound page, all human trials.