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A randomized comparative study of methylcobalamin, methylcobalamin plus pregabalin and methylcobalamin plus duloxetine in patients of painful diabetic neuropathy
Plain-language guide to PMID 34854403 (2021): open-label randomized controlled trial study of Cyanocobalamin (Vitamin B12) in 100 patients.
Key Facts
- PMID
- 34854403
- Journal
- Indian journal of pharmacology
- Year
- 2021
- Study type
- Randomized Controlled Trial
- Authors
- Sharma C et al. (5 authors)
- DOI
- 10.4103/ijp.ijp_1159_20
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Cyanocobalamin (Vitamin B12), published as a randomized controlled trial.
The results are expressed as mean ± standard deviation.
Who Took Part
According to the abstract, 100 patients were involved.
By PubMed's age tags, the people studied were middle-aged adults, both men and women.
It is a prospective, randomized, open-label, interventional, and parallel-group study done in patients of painful diabetic neuropathy.
A total of 100 patients were recruited and randomized to three study groups A, B, and C on methylcobalamin, methylcobalamin and pregabalin, and methylcobalamin and duloxetine, respectively.
How the Study Was Run
The researchers set it up as a randomized, open-label and parallel-group study.
Random assignment meant chance, not the researchers, decided who got Cyanocobalamin (Vitamin B12) and who got the comparison, which limits bias.
Nothing was hidden in this open-label Cyanocobalamin (Vitamin B12) study: the patients and staff both knew the treatment.
Groups ran in parallel: each of the patients stayed in one arm throughout.
Patients were assessed at day 0 and 4, 8, and 12 weeks.
The tuning fork test, monofilament test, Thermal Sensitivity testing, and Visual Analog Scale (VAS) were used to analyze vibration, pressure, thermal sensitivity, and pain.
What Was Measured
The subject headings attached to it are Analgesics, Diabetic Neuropathies, Duloxetine Hydrochloride, Pain Measurement, Pregabalin and Vitamin B 12.
Author keywords: methylcobalamin and painful diabetic neuropathy.
What This Means in Plain Language
The paper is a randomized, open-label and parallel-group study of Cyanocobalamin (Vitamin B12) in 100 patients.
Its findings take up roughly 4 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.
The publication is from 2021 (Indian journal of pharmacology), a journal based in India.
More context: the Cyanocobalamin (Vitamin B12) compound page, all human trials.
Our Notes on the Compound
Cyanocobalamin (Vitamin B12): A synthetic form of vitamin B12 (cobalamin), an essential nutrient for DNA synthesis, red blood cell formation and neurological function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.