Effect and Tolerability of a Nutritional Supplement Based on a Synergistic Combination of β-Glucans and Selenium- and Zinc-Enriched Saccharomyces cerevisiae (ABB C1®) in Volunteers Receiving the Influenza or the COVID-19 Vaccine: A Randomized, Double-Blind, Placebo-Controlled Study.

Plain-language guide to PMID 34959898 (2021): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc and Copper (Supplement) in 72 volunteers.

Key Facts

PMID: 34959898
Journal: Nutrients
Year: 2021
Study type: Randomized Controlled Trial
Authors: Rodriguez JAM et al. (7 authors)
DOI: 10.3390/nu13124347

What This Study Did, in Plain Language

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc and Copper (Supplement), published as a randomized controlled trial.

A single-center, randomized, double-blind, placebo-controlled study was conducted in 72 volunteers who received a synergistic combination of yeast-based ingredients with a unique β-1,3/1,6-glucan complex and a consortium of heat-treated probiotic Saccharomyces cerevisiae rich in selenium and zinc (ABB C1®) or placebo on the next day after getting vaccinated against influenza (Chiromas®) (n = 34) or the COVID-19 (Comirnaty®) (n = 38).

The duration of treatment was 30 and 35 days for the influenza and COVID-19 vaccine groups, respectively.

Who Took Part

According to the abstract, 72 volunteers were involved.

By PubMed's age tags, the people studied were middle-aged adults, both men and women.

How the Study Was Run

In design terms this was a randomized, double-blind and placebo-controlled study.

The volunteers were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

Blinding on both sides kept the volunteers and researchers unaware of who received Vitamin D, K2, Magnesium and Zinc.

A placebo (an inactive look-alike) gave the Vitamin D, K2, Magnesium and Zinc group a baseline to be compared against.

What Was Measured

Topics PubMed links to this paper include Antibodies, Viral, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, COVID-19 Vaccines, Dietary Supplements, Immunoglobulin G and Immunoglobulin M.

Author keywords: Saccharomyces cerevisiae, influenza vaccine, nutritional supplementation, selenium, trained immunity and zinc.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc and Copper (Supplement) in 72 volunteers.

The publication is from 2021 (Nutrients), a journal based in Switzerland.

More context: the Vitamin D, K2, Magnesium and Zinc compound page and the Copper (Supplement) compound page, all human trials.

Our Notes on the Compounds

Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.

Copper (Supplement): The active site of cytochrome c oxidase is described as containing copper ions that are essential for electron transfer.

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.