Vitamin D and Multiple Health Outcomes: An Umbrella Review of Observational Studies, Randomized Controlled Trials, and Mendelian Randomization Studies.

What It Covers

Researchers studied Vitamin D, K2, Magnesium and Zinc in this systematic review publication.

In the present umbrella review the researchers aimed to evaluate the effects of low vitamin D concentrations and vitamin D supplementation on multiple health outcomes.

Why It Was Studied

Observational studies, randomized controlled trials (RCTs), and Mendelian randomization (MR) studies have yielded inconsistent results on the associations of vitamin D concentrations with multiple health outcomes.

The researchers summarized current evidence obtained from meta-analyses of observational studies that examined associations between vitamin D concentrations and multiple health outcomes, meta-analyses of RCTs that investigated the effect of vitamin D supplementation on multiple health outcomes, and MR studies that explored the causal associations of vitamin D concentrations with various diseases (international prospective register of systematic reviews PROSPERO registration number CRD42018091434).

How the Review Was Done

A total of 296 meta-analyses of observational studies comprising 111 unique outcomes, 139 meta-analyses of RCTs comprising 46 unique outcomes, and 73 MR studies comprising 43 unique outcomes were included in the present umbrella review.

What Was Measured

Observational studies, randomized controlled trials (RCTs), and Mendelian randomization (MR) studies have yielded inconsistent results on the associations of vitamin D concentrations with multiple health outcomes.

The researchers summarized current evidence obtained from meta-analyses of observational studies that examined associations between vitamin D concentrations and multiple health outcomes, meta-analyses of RCTs that investigated the effect of vitamin D supplementation on multiple health outcomes, and MR studies that explored the causal associations of vitamin D concentrations with various diseases (international prospective register of systematic reviews PROSPERO registration number CRD42018091434).

The subject headings attached to it are Alzheimer Disease, Diabetes Mellitus, Type 2, Dietary Supplements, Hypertension, Mendelian Randomization Analysis, Randomized Controlled Trials as Topic and Systematic Reviews as Topic.

The authors tagged it with the keywords Mendelian randomization studies, meta-analysis, multiple health outcomes, observational studies, umbrella review and vitamin D deficiency.

What This Means in Plain Language

This is a systematic review of Vitamin D, K2, Magnesium and Zinc.

The publication is from 2022 (Advances in nutrition (Bethesda, Md.)), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.