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Effects of vitamin D-fortified oil intake versus vitamin D supplementation on vitamin D status and bone turnover factors: A double blind randomized clinical trial.
Plain-language guide to PMID 35063214 (2022): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 93 participants.
Key Facts
- PMID
- 35063214
- Journal
- Clinical nutrition ESPEN
- Year
- 2022
- Study type
- Randomized Controlled Trial
- Authors
- Ghasemifard N et al. (5 authors)
- DOI
- 10.1016/j.clnesp.2021.12.025
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.
The aim of this study was to compare the effect of vitamin D fortified oil consumption and vitamin D supplementation on serum 25-hydroxy vitamin D and bone turnover factors.
Who Took Part
According to the abstract, 93 participants were involved.
By PubMed's age tags, the people studied were teenagers, young adults and adults.
How the Study Was Run
In design terms this was a randomized, double-blind, placebo-controlled and parallel-group study.
The participants were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.
As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.
A placebo (an inactive look-alike) gave the Vitamin D, K2, Magnesium and Zinc group a baseline to be compared against.
The Vitamin D, K2, Magnesium and Zinc group and the comparison group ran side by side rather than switching.
Before and after the intervention 25-hydroxy vitamin D (25(OH)D1), parathyroid hormone (PTH2), bone alkaline phosphatase (BAP3) and collagen type 1 cross-linked C-telopeptide I (CTX4) were assessed.
What Was Measured
Topics PubMed links to this paper include Bone Remodeling, Dietary Supplements, Food, Fortified, Iran, Vitamin D and Vitamins.
Author keywords: Bone turnover, Clinical trial, Fortified oil and Supplementation.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 93 participants.
Its findings take up roughly 7 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.
The publication is from 2022 (Clinical nutrition ESPEN), a journal based in England.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.