The effect of vitamin D on the lipid profile as a risk factor for coronary heart disease in postmenopausal women: a meta-analysis and systematic review of randomized controlled trials.

Plain-language guide to PMID 35090975 (2022): meta-analysis of Vitamin D, K2, Magnesium and Zinc.

Key Facts

PMID: 35090975
Journal: Experimental gerontology
Year: 2022
Study type: Meta-Analysis
Authors: Zhang W et al. (8 authors)
DOI: 10.1016/j.exger.2022.111709

What This Paper Covers, in Plain Language

What It Covers

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a meta-analysis.

The exact effect of vitamin D administration on the lipid profile in postmenopausal women is unknown.

However, as dyslipidemia is a recognized risk factor for coronary heart disease (CHD) in this population, the lipid-lowering effects of vitamin D need to be explored Thus, the researchers conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) that evaluated the impact of vitamin D use on triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) as a risk factor for coronary heart disease (CHD) in postmenopausal women.

Who the Included Studies Covered

PubMed tags the participants as women only.

How the Review Was Done

The researchers developed a search strategy for multiple databases (PubMed/Medline, Scopus, Embase, and Web of Science) to identify relevant RCTs whose results were published until June 1st, 2021.

The researchers combined the results using a random effects model (the DerSimonian and Laird random effects model).

What Was Measured

Topics PubMed links to this paper include Coronary Disease, Dietary Supplements, Lipids, Postmenopause, Randomized Controlled Trials as Topic, Risk Factors and Vitamin D.

Author keywords: Coronary heart disease (CHD), Heart failure, Hypertension, LDL, Lipid profile and Postmenopausal women.

What This Means in Plain Language

This is a meta-analysis of Vitamin D, K2, Magnesium and Zinc.

The abstract goes on to report its results in about 7 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2022 (Experimental gerontology), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.

Our Notes on the Compound

Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.

Vitamin D, K2, Magnesium and Zinc in the library

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.